12 Largest Cities in Missouri [2025]

Missouri, often called the "Show-Me State," has a little bit of everything. You’ll find bustling cities, rich history, and plenty of charm. From the bluesy streets of St. Louis to the barbecue capital of Kansas City, the largest cities in Missouri each bring their own personality to the table.

In this article, we’ll take a closer look at 12 of the state’s biggest cities, highlighting what makes each one a great place to live, from job opportunities and schools to entertainment and housing options.

By the end, you’ll have a better sense of which Missouri city might be the perfect place to call home!

1. Kansas City, Missouri

• Population: 510,704
• Median 2-Bedroom Apartment Rent: $1,336
• Median Household Income: $65,256
• Walk Score: 35
• Transit Score: 23
• Bike Score: 30

Kansas City isn’t just about the barbecue—but let’s start there anyway. With iconic spots like Joe’s Kansas City Bar-B-Que and Q39, it’s a paradise for food lovers. Beyond the brisket, the city is a hub for job seekers, with strong industries in tech, healthcare, and engineering.

Companies like Cerner and Hallmark call Kansas City home, and the T-Mobile Center hosts world-class events. Families appreciate its affordable housing market and great schools like Park Hill and Blue Springs School Districts. Sports fans? You’ve got the Chiefs and Royals. As Missouri’s largest city, it offers plenty of opportunities, though the sprawling layout makes having a car essential.

2. St. Louis, Missouri

• Population: 281,754
• Median 2-Bedroom Apartment Rent: $1,242
• Median Household Income: $52,941
• Walk Score: 66
• Transit Score: 43
• Bike Score: 58

Home to the iconic Gateway Arch, St. Louis is rich in culture, history, and entertainment. It’s also incredibly family-friendly, thanks to attractions like the St. Louis Zoo (it’s free!) and the sprawling Forest Park, which is even larger than Central Park in NYC.

The city’s job market is bolstered by companies like Anheuser-Busch and Bayer, and St. Louis neighborhoods like Soulard and The Hill are famous for their food scenes—don’t leave without trying toasted ravioli. As one of Missouri’s biggest cities, St. Louis combines affordability with endless things to do, but crime can be an issue in some neighborhoods, so it’s worth doing your research.

3. Springfield, Missouri

• Population: 170,188
• Median 2-Bedroom Apartment Rent: $1,032
• Median Household Income: $43,450
• Walk Score: 39
• Transit Score: -
• Bike Score: 51

Springfield is where small-town charm meets urban convenience. Known as the “Queen City of the Ozarks,” it’s a gateway to outdoor adventures with spots like Fantastic Caverns and Lake Springfield.

Healthcare is a major industry here, with CoxHealth and Mercy Hospital as top employers. Its downtown area is growing, with trendy restaurants and local breweries like Mother’s Brewing Company. Affordable housing and a low cost of living make Springfield one of the most accessible major cities in Missouri, though its job market isn’t as diverse as larger urban centers.

4. Columbia, Missouri

• Population: $129,330
• Median 2-Bedroom Apartment Rent: $1,064
• Median Household Income: $60,455
• Walk Score: 30
• Transit Score: -
• Bike Score: 40

Home to the University of Missouri, Columbia is a vibrant college town with a progressive vibe. The university drives a lot of the local economy, but the city also thrives on healthcare and education sectors. Downtown Columbia is buzzing with energy, featuring cozy cafes like Lakota Coffee and eclectic eateries such as Addison’s. Nature lovers will appreciate Rock Bridge Memorial State Park for hiking and exploring. Columbia’s youthful population and cultural events, like the True/False Film Fest, make it a great choice for those who enjoy an active, engaged community. Its reputation as one of the most populated cities in Missouri is well-earned, with plenty to offer residents.

5. Independence, Missouri

• Population: $120,922
• Median 2-Bedroom Apartment Rent: $1,229
• Median Household Income: $57,415
• Walk Score: 28
• Transit Score: 19
• Bike Score: 28

Known for its historical charm, Independence is the hometown of President Harry S. Truman. History buffs will love visiting sites like the Truman Library & Museum or the 1859 Jail Museum. It’s also a family-friendly city with affordable housing, great schools, and plenty of parks like Waterfall Park. While it’s quieter compared to the big cities in Missouri, its proximity to Kansas City offers the best of both worlds: suburban comfort with easy access to urban amenities.

6. Lee’s Summit, Missouri

• Population: 104,184
• Median 2-Bedroom Apartment Rent: $1,459
• Median Household Income: $103,447
• Walk Score: 20
• Transit Score: -
• Bike Score: 29

Lee’s Summit is a top choice for families looking for strong schools, such as those in the Lee’s Summit R-7 School District, and a community-focused environment. Its historic downtown area is full of charm, with local shops and eateries like Third Street Social. Outdoor enthusiasts will appreciate Fleming Park, offering trails, lakes, and camping. Lee’s Summit might not compete with the biggest city in Missouri for nightlife, but it’s perfect for those who value safety, family amenities, and a suburban feel.

7. O’ Fallon, Missouri

• Population: 94,074
• Median 2-Bedroom Apartment Rent: $1,582
• Median Household Income: $104,863
• Walk Score: 22
• Transit Score: -
• Bike Score: 27

O’Fallon has become one of the fastest-growing cities in Missouri by population, and for good reason. It boasts excellent schools, strong job opportunities, and a welcoming community. Local attractions include Fort Zumwalt Park and a variety of events like the Heritage & Freedom Fest. With its mix of suburban living and modern conveniences, O’Fallon is a great alternative to the hustle and bustle of Missouri’s largest cities.

8. St. Charles, Missouri

• Population: 71,800
• Median 2-Bedroom Apartment Rent: $1,306
• Median Household Income: $83,589
• Walk Score: 33
• Transit Score:
• Bike Score: 30

Steeped in history, St. Charles offers a picturesque setting along the Missouri River. Its Main Street Historic District is packed with unique shops, restaurants, and festivals like the Festival of the Little Hills. The area also has a strong job market and schools that cater to growing families. St. Charles strikes a great balance—close enough to St. Louis for commuters yet peaceful enough for those wanting a quieter life. Its charm has helped it remain one of Missouri’s biggest cities with plenty to offer its residents.

9. St. Joseph, Missouri

• Population: 70,634
• Median 2-Bedroom Apartment Rent: $900
• Median Household Income: $54,415
• Walk Score: 32
• Transit Score: -
• Bike Score: 27

St. Joseph is a city of rich history and affordable living. As the starting point of the Pony Express, it offers unique attractions like the Pony Express Museum and the Jesse James Home Museum. While it’s not the largest city in Missouri, St. Joseph’s growing industries in healthcare and manufacturing provide plenty of job opportunities. Its housing market is also one of the most budget-friendly on this list, making it a practical choice for renters seeking a blend of history and opportunity.

10. Blue Springs, Missouri

• Population: 60,539
• Median 2-Bedroom Apartment Rent: $1,595
• Median Household Income: $82,965
• Walk Score: 25
• Transit Score:
• Bike Score: 31

Blue Springs is a family-focused city that combines suburban living with access to Kansas City. The Blue Springs School District is highly rated, and outdoor lovers enjoy Lake Jacomo for boating and fishing. Its thriving local economy and affordable housing make it a solid choice for those looking to live outside the biggest cities in Missouri while still having access to all the essentials.

11. Joplin, Missouri

• Population: 53,095
• Median 2-Bedroom Apartment Rent: $1,146
• Median Household Income: $50,996
• Walk Score: 35
• Transit Score:
• Bike Score: 44

Joplin is a hidden gem for those seeking affordability and small-town charm. With a strong community spirit and job opportunities in healthcare and retail, it’s a great place to plant roots. Locals love exploring Grand Falls, Missouri’s largest continuously flowing waterfall, and enjoying meals at spots like Red Onion Cafe. Though smaller than most major cities in Missouri, Joplin offers a high quality of life for renters on a budget.

12. Florissant, Missouri

• Population: 51,128
• Median 2-Bedroom Apartment Rent: $1,097
• Median Household Income: $64,178
• Walk Score: 39
• Transit Score: 26
• Bike Score: 39

Florissant is a historic suburb of St. Louis that offers affordable housing and a strong community feel. Known for its parks like St. Ferdinand Park and local events such as the Valley of Flowers Festival, Florissant has a lot to offer families and young professionals alike. While it doesn’t match the excitement of Missouri’s biggest cities, it’s an excellent option for those looking for a quieter place to call home with easy access to nearby urban areas.

Need Help Finding an Apartment in Missouri?

Missouri is packed with cities that cater to all kinds of lifestyles. Whether you’re drawn to the lively streets of Kansas City, the historic charm of St. Charles, or the peaceful vibe of Lee’s Summit, there’s a spot here that’s ready to feel like home.

Each of the biggest cities in Missouri has its own unique perks, making it easier than ever to find a place that fits your needs.

If you’re ready to find the perfect apartment, we at Apartment List can help simplify your search with our matching tool, which lets you narrow down options based on what matters most—whether it’s affordability, amenities, or proximity to work or school. Don’t settle for anything less than a place that checks all your boxes. Start exploring today and take the next step toward your new Missouri home!